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Our lab investigates the neural circuit mechanisms that underlie higher-level cognitive functions in macaques and humans. We integrate large-scale electrophysiological recordings, optogenetics, and computational modeling to study how the neural circuits support cognition.
Our research focuses on four interconnected directions:
Measuring how abstract, task-related information is encoded, transformed, and communicated across the cortico-striatal-thalamo-cortical network using simultaneous recordings from multiple brain regions;
Exploring the co-evolution of cognitive functions and neural circuits through cross-species comparisons;
Elucidating circuit-level mechanisms of cognitive dysfunction through animal models and clinical studies;
Validating the functional roles of neural circuits in cognition using brain–machine interfaces and neuromodulatory approaches.
Basal ganglia loops
Basal ganglia loops
Our research investigates the essential role of basal ganglia loops in modulating cognitive functions, with a specific emphasis on the functional topography of fronto-striato-thalamic circuits. We aim to elucidate the neural substrates governing complex, goal-directed behaviors and characterize the dopaminergic mechanisms that drive instrumental learning and adaptive decision-making
Human Vs. Macaque
Human Vs. Macaque
Our research investigates the evolutionary trajectory of cognitive functions across species, with a particular focus on the primate lineage. We seek to identify the unique neurobiological determinants of human intelligence and determine whether cognitive constraints—or 'bottlenecks'—observed in macaques are conserved or diverged in the human brain.
Boosting cognition
Boosting cognition
We investigate how to enhance cognitive performance through state-of-the-art neuromodulatory techniques. Specifically, we aim to evaluate the efficacy of closed-loop brain modulation and explore non-invasive strategies, such as transcranial Focused Ultrasound (tFUS) and gamma-frequency sensory entrainment, to precisely optimize neural oscillations and cognitive output.
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